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cialis is currently marketed in pill form for treating erectile dysfunction. adcirca is marketed for the treatment of pulmonary arterial hypertension. they should not be interchanged. tadalafil is a carboline- based compound with vasodilatory activity. tadalafil selectively inhibits the cyclic guanosine monophosphate ( cgmp) - specific type 5 phosphodiesterase- ( pde- 5) - mediated degradation of cgmp, which is found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis.


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  • in three placebo- controlled clinical trials of 12 or 24 weeks duration, mean age was 58 years ( range 21 to 82) and the discontinuation rate due to adverse events in patients treated with tadalafil was 4.
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